Subacute liver failure secondary to severe drug-related hepatotoxicity: case report
DOI:
https://doi.org/10.52784/27112330.124Keywords:
liver failure, drug-induced liver injury, toxicity, hepatitis, liver transplantation, amiodarone.Abstract
Acute liver failure is a rare disease with high mortality and a multitude of causes, including drug-induced liver injury, with a difficult differential diagnosis, particularly in the presence of polypharmacy. This pathology is associated with multisystemic organic failure which may require liver transplantation if patient stabilization is not achieved. We present the case of a 50-year-old woman with a 6-week history of right upper quadrant pain, nausea and generalized jaundice, who presented subacute liver failure which ultimately required liver transplantation. We describe the diagnostic approach towards the identification of a probable drug-related cause, due to the use of amiodarone, with a positive outcome for the patient after 3 years of post-transplant follow-up.
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